C01 C02 C04 C05 C06 C09 C10
Conditions
Interventions
Group 1: Test group
Within the test group, two breath samples are collected. The first sample is collected prior to surgery, the second 3-4 weeks after surgery.
Group 2: Control group
Within the contr
Sponsors
Charité Campus Charité Mitte
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: - Ability ( verbal , physically and mentally ) to understand the nature of the study and to participate - Willingness to study participation - Completed and signed informed consent - Age between 18 and 70 years - Karnofsky - Index : 80% - Smoking ( > 10 pack years , > 15 cigarettes / day ) - Regular alcohol consumption ( < 50 g / week ) Test group ( n = 15) Specific inclusion criteria - Histologically confirmed primary PECA in the region of the oral cavity and oropharynx - Surgical treatment pending Control group ( n = 5) No more than die inclusion criteria described above. Patients in both groups should be smokers and drink alcohol regularly to achieve a homogenous collective and in order to avoid overinterpretion of VOCs emitted through smoking/alcohol.
Exclusion criteria
Exclusion criteria: - Previous malignancies - Severe internal comorbidities (myocardial infarction, cardiomyopathy, NYHA functional class III / IV, severe COPD, renal failure, not controlled diabetes) - HIV infection - Drug addiction - Patients under 18 years old - Patients over 70 years - Karnofsky Index : < 80 % - Participation in a similar study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detectable tumor-specific signature VOCs at diagnosis with the help of gas chromatography and mass spectrometry | — |
Secondary
| Measure | Time frame |
|---|---|
| No detectable tumor-specific signature VOCs after surgery with the help of gas chromatography and mass spectrometry | — |
Countries
Germany
Contacts
Public ContactStefan Hartwig
Charité Campus Virchow-Klinikum
Outcome results
None listed