Analysis of extracellular vesicles and circulating microRNAs in remote ischemic preconditioning of coronary artery disease patients

Analysis of extracellular vesicles and circulating microRNAs in remote ischemic preconditioning of coronary artery disease patients - ExoRIP

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009435

Enrollment

100

Registered

2015-10-01

Start date

2016-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.1

Interventions

Group 1: Placebo: given the standard therapy, so no preconditioning, applying the blood pressure cuff but no pumping up the cuff Group 2: RIPC: gets preoperatively as part of the induction of anesthes

Eligibility

Sex/Gender

All

Age

45 Years to 85 Years

Inclusion criteria

Inclusion criteria: Coronary heart disease • CABG surgery with cardiopulmonary bypass • ages 45 to 85 years • Antegrade Bretschneider cardioplegia • Mild hypothermia (32C °) • Preoperative standard medication (statins, beta-blockers, aspirin) • Standard anesthesia (isoflurane, sufentanil) • Intraoperative standard protocol (full heparinization with ACT> 400s, aprotinin, protamine) • Postoperative standard protocol (500mg aspirin after 2 hours, Low-dose heparinization after 4h)

Exclusion criteria

Exclusion criteria: Condition after acute myocardial infarction • combined valvular • Emergency operation • catecholamine • Unstable angina • IABP mounting • pre- / intraoperative use of phosphodiesterase inhibitors • Diabetes mellitus • reoperation • COPD GOLD III and IV • renal insufficiency with creatinine> 1.5 mg / dl Dual antithrombotic therapy (clopidogrel + aspirin) Repeated cardiopulmonary bypass • Repeated cross clamping of the aorta • Intraoperative complications (bypass "low-flow" / -lock, frustrane valve reconstruction, Klappenausriss, aortic dissection, pump failure, implantation of cardiac assist systems) • aortic cross clamping> 150 min • Moderate / deep hypothermia (<32C °) • Antithrombotic therapy (intraoperatively clopidogrel u. / O. Aspirin) • Retrograde cardioplegia delivery

Design outcomes

Primary

Measure	Time frame
maximal postoperative troponin I increase within 7 days after coronary artery bypass surgery postoperatively	—

Secondary

Measure	Time frame
serum vesicle concentration serum micro-RNA concentration	—

Countries

Germany

Contacts

Public ContactUlrich Frey

Universitätsklinikum EssenKlinik für Anästhesiologie und Intensivmedizin

ulrich.frey@uk-essen.de+49 201 723 1401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026