CMR based myocardial tissue characterization in correlation with functional and flow-dynamic processes in patients with severe aortic stenosis prior to and after TAVI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009370

Enrollment

Registered

2015-09-17

Start date

2015-11-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I35.0

Interventions

Group 1: Patients with severe aortic stenosis will be examined prior to and 6 months after TAVI using novel MR techniques (T1 mapping, feature tracking, 4D flow) as well as established MR techniques (

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with severe aortic stenosis who will undergo a TAVI procedure. Control group: Healthy volunteers without any known heart disease.

Exclusion criteria

Exclusion criteria: MR contraindications (pacemakers, insulin pumps, cochlea implants, etc.); severe renal insufficiency (GFR < 30 ml/min); hemodynamic significant heart insufficiency that would lead to relevant additional stress for the patient during the examination.

Design outcomes

Primary

Measure	Time frame
After acquisition of CMR data before and 6 months after TAVI, all data (T1, strain, flow parameters, volumetry, late enhancement) will be quantified using various software algorithms. All data of both examinations will be compared to the group of healthy volunteers.	—

Countries

Germany

Contacts

Public ContactBettina Baeßler

Uniklinik Köln, Institut für Diagnostische und Interventionelle Radiologie

bettina.baessler@uk-koeln.de0221-478-5665

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026