F60.31
Conditions
Interventions
Group 1: Treatment group: 25 patients with BPD. In a diagnostic session, diagnostics of psychiatric disorders are conducted. For BPD diagnosis, the International Personality Disorder Examination (IPDE
Sponsors
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Current BPD (= 4 DSM-V criteria), female, informed consent for study participation
Exclusion criteria
Exclusion criteria: Psychotropic medication with tranquilizers, lifetime diagnosis of schizophrenia or bipolar I, substance dependence in the preceding year, current substance use, pregnancy, epilepsy, antecedent cranial or brain injuries, organic brain diseases, severe medical or neurological condition, BMI<16.5, metallic non-removable items in or on the body which are not MR compatible, permanent make-up, claustrophobia, left-handedness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Target criterion: Improvement of emotion regulation. Measures: Questionnaire: Difficulties in Emotion Regulation Scale (DERS); Peripheral physiologic measures: Fear-potentiated startle with instructed emotion regulation vs. natural responding to emotional pictures, heart rate variability (relation of high vs. low frequencies in spectrum). Central nervous system measures: amygdala BOLD response to masked affective facial expressions, amygdala BOLD response in Sternberg-Working Memory test with emotional vs. neutral distractor images. Acquisition times: T0: Treatment group: max 7 days before first training session (depends on patient's availability), T1: max 7 days after third training session, T2 (Follow up): 6 weeks after T1 | — |
Secondary
| Measure | Time frame |
|---|---|
| Target criterion: Reduction of BPD symptom severity. Measures: ZAN-BPD structured interview (acquisition in T0 and T2), BSL-23 self-report questionnaire (acquisition in T0, T1, T2; time lag matched to treatment group). | — |
Countries
Germany
Contacts
Public ContactChristian Paret
Central Institute of Mental Health
Outcome results
None listed