Sleeping behavior and Memory consolidation in patients with severe disorders of consciousness. Substudy 1: Sleep screening of patients in persistent vegetative state

Sleeping behavior and Memory consolidation in patients with severe disorders of consciousness. Substudy 1: Sleep screening of patients in persistent vegetative state - NeuRED

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00009326

Enrollment

Registered

2016-02-15

Start date

2016-04-21

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G93.80 G82 G61.0

Interventions

Group 1: In VS and MCS patients a one-time 24 hour recording of sleeping behavior is conducted. The EEG-channels F3, Fz, F4, C3, Cz, C4, P3, Pz, P4 the electrooculogramm (EOG1, EOG2) and the electromy

Eligibility

Sex/Gender

All

Age

18 Years to 69 Years

Inclusion criteria

Inclusion criteria: Patientgroup 1: -Non-traumatic or traumatic brain damage (e.g. hypoxia, ischemic and hemorrhagic cerebral infarction) -VS or MCS diagnose (classification according to CRSr, Coma Recovery Scale – revised). stratification: 20 MCS patients, 20 VS patients -injury occurred between 4 weeks and 12 month ago -stabile vital functions (blood pressure, pulse, temperature) Patientgroup 2: - Patient, who is confined to his/her bed with the diagnose Paraparese, Paraplegie, Tetraparese, Tetraplegie (G82) or Gullain-Barré-Syndrom (G61.0) -stabile vital functions (blood pressure, pulse, temperature)

Exclusion criteria

Exclusion criteria: -Severe slowdown of EEG-Basicactivity (1 - 3 Hz)

Design outcomes

Primary

Measure	Time frame
For each patient a one-time 24 hour recording of sleeping behavior is conducted. The EEG-channels F3, Fz, F4, C3, Cz, C4, P3, Pz, P4 the electrooculogramm (EOG1, EOG2) and the electromyogramm (EMG1, EMG2, EMG3) are recorded. In addition two referential electrodes are attached and a video recording for data evaluation is made. Before sleep recording a short EEG-measurement, during which in the form of an oddball-paradigm participants are stimulated on a auditive and tactile level is conducted. Via the evaluation of the EEG-/ EOG- and EMG-recordings (according to Rechtschafen & Kales, 1968 and Valente et al., 2002) an estimation of sleep is planed. In epochs with electromagnetic interference the video recordings should give clarity on the underlying events.	—

Measure

Time frame

For each patient a one-time 24 hour recording of sleeping behavior is conducted. The EEG-channels F3, Fz, F4, C3, Cz, C4, P3, Pz, P4 the electrooculogramm (EOG1, EOG2) and the electromyogramm (EMG1, EMG2, EMG3) are recorded. In addition two referential electrodes are attached and a video recording for data evaluation is made. Before sleep recording a short EEG-measurement, during which in the form of an oddball-paradigm participants are stimulated on a auditive and tactile level is conducted. Via the evaluation of the EEG-/ EOG- and EMG-recordings (according to Rechtschafen & Kales, 1968 and Valente et al., 2002) an estimation of sleep is planed. In epochs with electromagnetic interference the video recordings should give clarity on the underlying events.

—

Secondary

Measure	Time frame
There are no secondary endpoints required.	—

Countries

Germany

Contacts

Public ContactFriedemann Müller

Schoen Klinik Bad Aibling

fmueller@schoen-kliniken.de+49 (0) 8061-903-0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026