I25.1 I70.2
Conditions
Interventions
Group 1: Healthy volunteers: one-time blood draw, rewiev of medical history
Group 2: Patients with coronary artery disease: one-time blood draw, rewiev of medical history
Group 3: Patients with periph
Sponsors
Charité Universitätsmedizin BerlinKlinik für KardiologieCampus Benjamin Franklin
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. in all groups age between 30 and 75 years 2. in all groups male and female subjects Age and sex should be homogenously distributed among study arms Group 1: healthy volunteers (i.e. no known cardiac disease, no family history) Group 2: patients with stable coronary artery disease Groups 3: patients with peripheral artery occlusive disease
Exclusion criteria
Exclusion criteria: 1. pregnancy 2. renal failure (creatinin >265 umol) 3. liver failure 4. disease of the hematopoetic system 5. malignancy within the past 5 years (without evidence of relapse at time of inclusion) 6. acute or chronic inflammation 7. acute vascular event (e.g. myocardial infarction, stroke, pulmonary or systemic embolism) within the last year 8. inability to give informed consent 9. solid organ transplantation in history 10. acute shock 11. metabolic diseases including heredetary lipometabolic diseases and diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microvesicle secretion profiles of different circulating leukocytes in healthy subjects and patients with coronary artery disease or peripheral artery occlusive disease | — |
Secondary
| Measure | Time frame |
|---|---|
| Microvesicle function in different leukocyte populations in healthy subjects and patients with coronary artery disease or peripheral artery occlusive disease | — |
Countries
Germany
Contacts
Public ContactJulia-Christine Jordan
Charité Universitätsmedizin BerlinKlinik für KardiologieCampus Benjamin Franklin
Outcome results
None listed