Intestinal microbiota composition and diversity in very low and extremely low birthweigt infants related to strategies of NEC prophylaxis - a pilot study

Conditions

Necrotizing Enterocolitis P77

Charlotte Neumann, Alexander Mahnert, Christina Kumpitsch, Raymond Kiu, Matthew J. Dalby et al. (12 authors)

Nature Communications2023-03-1129 citations

Hospital Regimens Including Probiotics Guide the Individual Development of the Gut Microbiome of Very Low Birth Weight Infants in the First Two Weeks of Life

Stefan Kurath‐Koller, Charlotte Neumann, Christine Moissl‐Eichinger, Raimund Kraschl, Claudia Kanduth et al. (9 authors)

Nutrients2020-04-2827 citations

10.3390/nu12051256

Changes of intestinal microbiota composition and diversity in very low birth weight infants related to strategies of NEC prophylaxis: protocol for an observational multicentre pilot study.

Kurath-Koller S, Moissl-Eichinger C, Gorkiewicz G, Kraschl R, Kanduth C, Hopfer B, Urlesberger B, Resch B.

2017-11-074 citations

10.1186/s40814-017-0195-y

Interventions

Group 1: Preterm infants <1500g, treated at the Neonatology ward, Department of Pediatrics, Medical University Graz. NEC prophylaxis used at the Neonatology ward, Department of Pediatrics, Medical Uni

Eligibility

Sex/Gender

All

Age

No minimum to 2 Weeks

Inclusion criteria

Inclusion criteria: All infants treated at the Neonatology ward, Department of Pediatrics, Medical University Graz, and at the Neonatology ward, Department of Pediatrics, General hospital of Klagenfurt, or general hospital of Leoben between October 2015 and March 2017, having a birth weight <1500g.

Exclusion criteria

Exclusion criteria: Non viable at birth, death within the first two weeks of life, genetic syndrome disease, malformation, meconium transit disorder.

Design outcomes

Primary

Measure	Time frame
Monitoring changes in composition and diversity of intestinal microbiota in preterm born infants <1500g birth weight within the first weeks of life receiving NEC (necrotizing enterocolitis)-prophylaxis vs not receiving NEC-prophylaxis. Collection of stool samples every 2 days within the first two weeks of life and analysis from microbiota diversity and abundance.	—

Secondary

Measure	Time frame
Differences in NEC-incidence between the two groups.	—

Countries

Austria

Contacts

Public ContactBernhard Resch

Division of Neonatology, Department of Pediatrics, Medical University Graz, Austria

bernhard.resch@medunigraz.at004331638581134

Outcome results

None listed