Relevance of endogenous conditioned pain modulation (CPM) for hyperalgesia following a first-degree burn-injury in healthy volunteers.

Relevance of endogenous conditioned pain modulation (CPM) for hyperalgesia following a first-degree burn-injury in healthy volunteers. - Burn-injury Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009252

Enrollment

Registered

2015-10-21

Start date

2015-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endogenous pain inhibition and sensitization mechanisms leading to acute and chronic pain healthy volunteers

Interventions

Group 1: First, pain inhibition will be assessed by conditioned pain modulation (CPM). Afterwards, a standardized first-degree burn will be given. (first degree burn-injury (47ºC, 7 min, 9cm², medial

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: healthy volunteers

Exclusion criteria

Exclusion criteria: - intake of analgesics or psychopharmaca - chronic pain condition - neurological condition - diabetes mellitus - hypertension - pregnancy - intake of oral contraception

Design outcomes

Primary

Measure	Time frame
Correlation between Conditioned Pain Modulation Effect and the magnitude of secondary hyperalgesia before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury Measurement of Conditioned Pain Modulation Effect: painful stimulation with contact heat before, during and after immersing their contralateral hand in painful cold water (conditioned stimulation). The degree by which the conditioning stimulation affects the contact heat stimulus reflects pain inhibition. Measurement of secondary hyperalgesia: an area of augmented pain sensitivity, which is mediated by the central nervous system, develops surrounding the burn. This area reflects central sensitization.	—

Measure

Time frame

Correlation between Conditioned Pain Modulation Effect and the magnitude of secondary hyperalgesia before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury Measurement of Conditioned Pain Modulation Effect: painful stimulation with contact heat before, during and after immersing their contralateral hand in painful cold water (conditioned stimulation). The degree by which the conditioning stimulation affects the contact heat stimulus reflects pain inhibition. Measurement of secondary hyperalgesia: an area of augmented pain sensitivity, which is mediated by the central nervous system, develops surrounding the burn. This area reflects central sensitization.

—

Secondary

Measure	Time frame
Correlation between Conditioned Pain Modulation and thermal and mechanical thresholds and mechanical pain sensitivity before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury; Differences across gender and menstrual cycle (folicular phase, luteal phase) in women regarding the above mentioned parameters before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury; correlation between sex hormone levels (estrogene, progesterone, testosterone, FSH, LH) and the above mentioned parameters before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury	—

Measure

Time frame

Correlation between Conditioned Pain Modulation and thermal and mechanical thresholds and mechanical pain sensitivity before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury; Differences across gender and menstrual cycle (folicular phase, luteal phase) in women regarding the above mentioned parameters before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury; correlation between sex hormone levels (estrogene, progesterone, testosterone, FSH, LH) and the above mentioned parameters before and 1, 3, 9 and 24 hours after induction of the experimental burn-injury

—

Countries

Germany

Contacts

Public ContactEsther Pogatzki-Zahn

Universitätsklinikum MünsterKlinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

pogatzki@anit.uni-muenster.de0251/8347255

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026