Non-medical prescription opioid use and its neuropsychological predispositions and consequences.

Non-medical prescription opioid use and its neuropsychological predispositions and consequences. - NMPOU_1

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00009039

Enrollment

Registered

2015-08-12

Start date

2015-11-22

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-medical prescription opiod users F11.2

Interventions

Group 1: In NMPOU group: Examination of cognitive functioning using Cambridge Neuropsychological Test Automated Battery (CANTAB) and investigation of socio-cognitive functioning using Comprehensive Af

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: - Proficiency in German language - Absence of acute or prior physical illness and psychiatric disorders - opioid dependent subjects or healthy drug-naïve controls

Exclusion criteria

Exclusion criteria: - Polydrug consumption - presence of neurological disorders or brain injury

Design outcomes

Primary

Measure	Time frame
Social cognition (i.e. empathy, theory of mind, and emotion perception abilities) will be assessed by using "Movie of the Assessment for Social Cognition" (MASC), "Multifaceted Empathy Test" (MET), and "Comprehensive Affect Test System" (CATS). Social pain as ostracism will be measured by the "Cyberballl" task and empathy for pain will be examined by the "Empathy for Pain" task. Endocrinological parameters (cortisol, alpha amylase, ACTH, and oxytocin) will be assessed by saliva and blood samples during the last two tasks. Additionally, electrophysiological stress responses as skin conductance response and heart rate will be recorded. Six months later, participants will be re-invited for a follow-up testing session depending on subjects availability. The procedure and examination as well as the experimental environment will be equal to the first visit (parallel version of the tests will be conducted if applicable).	—

Measure

Time frame

Social cognition (i.e. empathy, theory of mind, and emotion perception abilities) will be assessed by using "Movie of the Assessment for Social Cognition" (MASC), "Multifaceted Empathy Test" (MET), and "Comprehensive Affect Test System" (CATS). Social pain as ostracism will be measured by the "Cyberballl" task and empathy for pain will be examined by the "Empathy for Pain" task. Endocrinological parameters (cortisol, alpha amylase, ACTH, and oxytocin) will be assessed by saliva and blood samples during the last two tasks. Additionally, electrophysiological stress responses as skin conductance response and heart rate will be recorded. Six months later, participants will be re-invited for a follow-up testing session depending on subjects availability. The procedure and examination as well as the experimental environment will be equal to the first visit (parallel version of the tests will be conducted if applicable).

—

Secondary

Measure	Time frame
The assessment of cognitive functioning will contain the following subtests of the CANTAB test battery: Rapid Visual Processing (RVP) for sustained attention, Paired Associates Learning (PAL) for visuo-spatial memory, Spatial Working Memory (SWM) for working memory/executive functioning, Intra-/Extradimensional set shifting (IED) for executive functions, and Stop-Signal Task (SST) for measuring impulse control. Additional cognitive task will be: Rey Auditory Verbal Learning Test (RAVLT) for verbal memory, Letter Number Sequencing Task (LNST) for working memory, and Delay Discounting task (DD) for decision making and impulsivity.	—

Measure

Time frame

The assessment of cognitive functioning will contain the following subtests of the CANTAB test battery: Rapid Visual Processing (RVP) for sustained attention, Paired Associates Learning (PAL) for visuo-spatial memory, Spatial Working Memory (SWM) for working memory/executive functioning, Intra-/Extradimensional set shifting (IED) for executive functions, and Stop-Signal Task (SST) for measuring impulse control. Additional cognitive task will be: Rey Auditory Verbal Learning Test (RAVLT) for verbal memory, Letter Number Sequencing Task (LNST) for working memory, and Delay Discounting task (DD) for decision making and impulsivity.

—

Countries

Switzerland

Contacts

Public ContactSara Liane Kroll

Psychiatrische Universitätsklinik ZürichExperimentelle und Klinische Pharmakopsychologie

saraliane.kroll@bli.uzh.ch0041 44 384 26 18

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026