OPS-2015: 8-98f (Complex intensive care treatments) N17
Conditions
Interventions
Group 1: Ischemic conditioning:
Three cycles of upper limb ischemia (5-min blood-pressure cuff inflation to a pressure that is 50 mm Hg higher than the systolic arterial pressure followed by 5 min cuf
Sponsors
Universitätsklinikum Münster Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: - critically ill patients on mechanical ventilator and analgosedation for at least 24 hours - requirement of catecholamines (Epi/Norepi >= 0.1 µg/kg/min) - unlimited intensive treatment for at least 2 days - informed consent
Exclusion criteria
Exclusion criteria: - pregnancy - History of unobserved circulatory arrest - refusal of intensive care treatment or life-prolonging measures - drug therapy with oral antidiabetics, sulfonamides, nicorandil - Participation on another clinical intervention trial - Persons with any kind of dependency to the investigator or employed by the sponsor or investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compliance with the study protocol | — |
Secondary
| Measure | Time frame |
|---|---|
| - proportion of randomised patients - frequency of patients with follow-up after 90 days - Severity of acute kidney injury - incidence of acute kidney injury - requirement for renal replacement therapy - mortality - biomarker | — |
Countries
Germany
Contacts
Public ContactCarola Wempe
Universitätsklinikum Münster Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Outcome results
None listed