E66
Conditions
Interventions
Group 1: 20-30 obese patients (BMI = 40 kg/m2) undergoing laparoscopic sleeve gastrectomy are included in the study. Before and six months after surgery the intestinal permeability is investigated by
Sponsors
Else Kröner-Fresenius Zentrum für Ernährungsmedizn, Lehrstuhl für Ernährungsmedizin, Technische Universität München
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: written informed consent, BMI = 40 kg/m² for the bariatric surgery group, BMI < 30 kg/m² for the control group
Exclusion criteria
Exclusion criteria: absent written informed consent, poor complicance, serious illness, e.g. cancer, COPD, serious hart disease (e.g. pacemaker), serious mental illness, liver illness (AST, ALT > 3fold of normal value), renal disease (creatinine > 1.2 mg/dl), serious gastrointestinal, neurological, rheumatic illness, celiac disease, acute infections, hypokalemia, insulin-dependent diabetes mellitus, regular intake of antibiotics, immunesuppressants, laxatives, anti-diarrhea medication, malabsorption syndrome, autonomic neuropathy, lactulose intolerance, sucralose intolerance, sucrose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intestinal permeability: sugar resorption test; change in microbial composition of the colon: faecal sample, metagenomic sequencing of faecal microbiota; inflammatory parameters in blood: blood samples, CRP; marker of intestinal permeability in blood: blood samples, zonulin and LPS-binding protein; all parameters are measured before as well as six months after sugery in the obese patients and once in the control patients | — |
Secondary
| Measure | Time frame |
|---|---|
| anthropometry: body weight as well as waist-to-hip ratio; eating habits: 7 day dietary protocol; fasting insulin, fasting glucose, HbA1c: blood samples, laboratory analysis all parameters are measured before as well as six months after sugery in the obese patients and once in the control patients | — |
Countries
Germany
Contacts
Public ContactTeresa Kellerer
Lehrstuhl für Ernährungsmedizin, Technische Universität München
Outcome results
None listed