opioid induced hyperalgesia (OIH) R20.8
Conditions
Interventions
Group 1: Remifentanil (0.4 µg/kg/min) based total intravenous anesthesia
Group 2: Sufentanil (0,25 µg/kg) based total intravenous anesthesia
Sponsors
Universitätsklinikum Schleswig-Holstein,Campus Kiel,Klinik für Anästhesiologie und Operative Intensivmedizin
Eligibility
Sex/Gender
Female
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age >18 years ASA physical status I-III elective surgery of the female breast, including segmental resections or mastectomy with or without sentinel lymph node biopsy written informed consent
Exclusion criteria
Exclusion criteria: allergies to remifentanil, sufentanil or paracetamol, preoperative acute or chronic pain states, preoperative intake of any analgesic drugs, history of drug or alcohol abuse, renal insufficiency (serum creatinin >1,5 mg/dl), impaired liver function (GTT >100U/l), neurologic diseases that might have an impact on QST (PNP, ED), gravidity, diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensory thresholds (quantitative sensory testing) 22h postoperative | — |
Countries
Germany
Contacts
Public ContactHenning Ohnesorge
UKSH, Campus Kile, Klinik für Anästhesiologie und Operative Intensivmedizin
Outcome results
None listed