R42 H81 H81.4 H81.3 R26 H53 H55 R11
Conditions
Interventions
Group 1: Experimental intervention / index test:
Specialized clinical and apparative neurophysiological testing as a basis for future diagnostic index test (e.g. videooculography, video head impulse
Sponsors
Klinikum der Universität München, Campus Großhadern
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with acute onset of vertigo, dizziness, double vision, gait or balance problems within the last 24 hours (symptoms lasting at least 10 min)
Exclusion criteria
Exclusion criteria: Age under 18 years, proven cental or peripheral aetiology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint (stroke or no stroke) will be determined on the basis of the reference test (MRI, clinical observation). A first outcome measure is the a-priori probability of stroke. The main goal is to develop a diagnostic index test for stroke in patients with acute vertigo, dizziness, and imbalance. Clinical and neurophysiological test results (e.g. ocular motor signs on video-oculography, video head impulse testing, posturography, SVV, TuG, clinical scores) will be combined to a diagnostic score for the risk of stroke (predictor). | — |
Secondary
| Measure | Time frame |
|---|---|
| The second outcome measure will be sensitivity and specificity, the pair of diagnostic quality of the index test. The index test will be determined based on the Receiver Operating Characteristic curve (ROC) according to the diagnostic score with specific cut-off values for sensitivity and specificity in order to develop a stroke detection test with high sensitivity and acceptable specificity. | — |
Countries
Germany
Contacts
Public ContactKen Möhwald
Klinikum der Universität München, Campus Großhadern, Deutsches Schwindel- und Gleichgewichtszentrum (DSGZ)
Outcome results
None listed