PsYchoTHerapy - Intergenerational Actions

PsYchoTHerapy - Intergenerational Actions - PYTHIA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00008932

Enrollment

Registered

2015-07-27

Start date

2015-08-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F34

Interventions

Group 1: chronically depressed patients with good clinical response to CBASP psychotherapy (10 weeks of inpatient psychotherapy, twice 90 minutes group psychotherapy per week, once 45 minutes individu

Eligibility

Sex/Gender

Male

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: chronic depression with early onset, clinical indication for CBASP, male, 18 - 65 years, german language skills, ability to consent; for healthy controls: exclusion of mood disorders

Exclusion criteria

Exclusion criteria: evidence for organic affective disorder, bipolar I affective disorder or schizophrenia; evidence for major urologic disorder; polypharmacy; use of steroid hormones

Design outcomes

Primary

Measure	Time frame
clinical response to psychotherapy as measured by standard instruments (before and after therapy: CGI; weekly: MADRS); DNA methylation: Lab method: Infinium HumanMethylation450 BeadChip; Time points of measures: before therapy (blood, saliva, sperm), end of psychotherapy (blood, saliva), 8 weeks after end of psychotherapy (blood, saliva, sperm)	—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de0621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026