Dynamics of cardiovascular autonomic disturbances in acute ischemic cerebral infarction

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00008931

Enrollment

100

Registered

2015-07-20

Start date

2009-04-14

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy participants I63.9

Interventions

Group 1: patients with ischemic stroke - we will record heart rate, blood pressure, respiratory frequency, oxygen saturation within 24 hours after stroke onset, and on the 2nd, 3rd, and 4th day after

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with acute supratentorial ischemic stroke, who can be measured within 24 hours after stroke onset.

Exclusion criteria

Exclusion criteria: Patients with a history of stroke, pre-existing cardiovascular disease, diabetes mellitus or other disease or medication known to affect the autonomic nervous system are excluded from the study. Patients with cardiac arrhythmias or pace-maker will also be excluded.

Design outcomes

Primary

Measure	Time frame
For this study, no end-points were defined. Aim of the study is to identify dynamics of sympathetic and parasympathetic cardiovascular dysregulation during the first 4 days after stroke in relation to the localization of the stroke. For 5 minutes at supine rest we will continuosly record heart rate using conventional three-lead electrocardiography. Beat-to-beat systolic and diastolic blood pressures will be monitored non-invasively at the index or middle finger of the non-paretic hand using the vascular unloading technique (CNAP™ -System, Dräger Medical, Deutschland). Respiratory frequency will be monitored by chest impedance measurements. Transcutaneous oxygen saturation will be measured by means of finger pulsoxymetry. Zusätzlich wird mehrmals täglich im Rahmen der normalen Überwachung auf der Stroke-Unit der klinische Schweregrad mittels NIHSS-score bestimmt. Additionaly, as part of the usual routine work on stroke-unit, clinical impairment by means of the NIHSS-score will be assessed.	—

Measure

Time frame

For this study, no end-points were defined. Aim of the study is to identify dynamics of sympathetic and parasympathetic cardiovascular dysregulation during the first 4 days after stroke in relation to the localization of the stroke. For 5 minutes at supine rest we will continuosly record heart rate using conventional three-lead electrocardiography. Beat-to-beat systolic and diastolic blood pressures will be monitored non-invasively at the index or middle finger of the non-paretic hand using the vascular unloading technique (CNAP™ -System, Dräger Medical, Deutschland). Respiratory frequency will be monitored by chest impedance measurements. Transcutaneous oxygen saturation will be measured by means of finger pulsoxymetry. Zusätzlich wird mehrmals täglich im Rahmen der normalen Überwachung auf der Stroke-Unit der klinische Schweregrad mittels NIHSS-score bestimmt. Additionaly, as part of the usual routine work on stroke-unit, clinical impairment by means of the NIHSS-score will be assessed.

—

Secondary

Measure	Time frame
For this study, no secondary end-points were defined	—

Countries

Germany

Contacts

Public ContactMax J. Hilz

Neurologische Universitätsklinik Erlangen

max.hilz@uk-erlangen.de+49 9131 8534444

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026