Application of the positive endexpiratory pressure (PEEP) based on intratidal respiratory system mechanics compared with the empirical setting

Application of the positive endexpiratory pressure (PEEP) based on intratidal respiratory system mechanics compared with the empirical setting - GUI-OP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00008924

Enrollment

Registered

2015-08-10

Start date

2015-11-05

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative artificial ventilation Healthy volunteers with different diagnosis

Interventions

Group 1: 30 healthy volunteers will be given the commonly used positive endexspiratory pressure (PEEP) of 5mbar for the complete duration of the surgery. Group 2: Positive endexspiratory pressure (PEE

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: adults of at least 18 years of age, informed written consent, elective surgery, artificial ventilation

Exclusion criteria

Exclusion criteria: known pulmonary disease, cardiac pacemaker, automated implantable cardioverter-defibrillator or other active implants, heart defects, laparoscopic surgery

Design outcomes

Primary

Measure	Time frame
Perioperative non-linear intratidal compliance, continously measured [ml/mbar] from the end of induction until the end of the surgery	—

Secondary

Measure	Time frame
Continuously measured perioperative regional ventilation (using EIT (electrical impedance tomography) - pixel) as well as Oxygenation (SaO2, PaO2), drawn from standard-monitoring, from the end of induction until the end of the surgery	—

Countries

Germany

Contacts

Public ContactSteffen Wirth

Klinik für Anästhesiologie und IntensivmedizinUniversitätsklinikum Freiburg

steffen.wirth@uniklinik-freiburg.de+49761270240101

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 19, 2026