Activity of stress-related systems, metabolic consequences and genetics of restless legs syndrome, periodic limb movements, parasomnias, narcolepsy and healthy controls

Activity of stress-related systems, metabolic consequences and genetics of restless legs syndrome, periodic limb movements, parasomnias, narcolepsy and healthy controls - ASS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00008902

Enrollment

1000

Registered

2015-07-13

Start date

2011-08-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F51.0 G25.8 G47.4

Interventions

Group 1: primary insomnia (analysis of existing blood samples) Group 2: Restless legs syndrome (analysis of existing blood samples) Group 3: narcolepsy + other parasomnias (analysis of existing blood

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patients with sleep disorder (see above) that is confirmed by polysomnography

Exclusion criteria

Exclusion criteria: inability to consent

Design outcomes

Primary

Measure	Time frame
Endpoints are metabolic features (cholesterol, fasting glucose etc.) and endocrinological parameters (adipokines, BDNF and others) in blood samples that are collected in the framework of a clinical routine blood withdrawal. Relevant endpoints are laboratory features of the metabolic syndrome (triglycerides, LDL-, HDL- and total cholesterol, fasting glucose) as well as endocrinological variables like adipokines (proteins secreted by fat tissue like leptin, adiponektin) and growth factors, like insulin-like growth factor-1 (IGF-1) and brain-derived neurotrophic factor (BDNF). Cortisol in night urine is an independent variable, which - as well as polysomnography and clinical diagnoses - is relevant for the determination of study groups.	—

Measure

Time frame

Endpoints are metabolic features (cholesterol, fasting glucose etc.) and endocrinological parameters (adipokines, BDNF and others) in blood samples that are collected in the framework of a clinical routine blood withdrawal. Relevant endpoints are laboratory features of the metabolic syndrome (triglycerides, LDL-, HDL- and total cholesterol, fasting glucose) as well as endocrinological variables like adipokines (proteins secreted by fat tissue like leptin, adiponektin) and growth factors, like insulin-like growth factor-1 (IGF-1) and brain-derived neurotrophic factor (BDNF). Cortisol in night urine is an independent variable, which - as well as polysomnography and clinical diagnoses - is relevant for the determination of study groups.

—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de0621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 25, 2026