Healthy Subjects G20
Conditions
Interventions
Group 1: healthy control subjects of the same age
Group 2: Parkinson's patients: EEG recording without medication in the state of bad mobility, "off"-state, standardized dose of dopaminergic drug (Mad
Sponsors
AG für Bewegungsstörungen und Tiefe HirnstimulationKlinik und Poliklinik für Neurologie und PsychiatrieUniklinikum Köln
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Healthy subjects: • Male and female participants between 30 and 80 years of age • Right handed persons • Capability of signing an informed consent Parkinson’s patients: • Male and female patients with the diagnosis of an IPS according to the guidelines of the DGN • Right handed patients • positive motor response to L-Dopa or Apomorphine; • Patients between 30 and 80 (in order to exclude genetic variants of the disease); • time period of the symptomes longer than 4 years (differential diagnosis); • patients have to be able to sign an informed consent; • Ability to cooperate during the measurements
Exclusion criteria
Exclusion criteria: Healthy subjects: • non- "sui juris" patients, underaged persons as well as subjects which are judically sent to an institution • diagnosis of an idiopathic parkinson syndrom or any other neurological disease • participants that take drugs regularly which influence the nervous system and which can not be stopped the evening before the experiment • severe internal comorbidities • presence of psychiatric diseases •impaired vision or hearing defect that may hinder the testing • pregnant or breast feeding mothers Parkinson’s patients: • non- "sui juris" patients, underaged persons as well as subjects which are judically sent to an institution • patients that suffer from another neurological disease apart from Parkinsons like Epilepsy, Alzheimers or Dystonia • patients with severe frontal executive disturbances • presence of a Parkinson-Plus-Syndrom like corticobasal degeneration, progressive supranuclear palsy or multisystem atrophy • other hypokinetic movement disorders like MPTP- or manganese intoxication, chorea Huntington, subcortical arteriosclerotic encephalopathy or psychogenic movement disorder • clinically relevant abnormalities in preoperative MR-Images like ischemia, or cerebral athropy • previous surgeries in the ZNS due to, for example, brain tumors, epilepsy or vascular reasons • severe internal comorbidities • presence of psychiatric diseases • impaired vision or hearing defect that may hinder the testing • pregnant or breast feeding mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological coupling of motor related brain areas in Parkinson's patients compared to healthy subjects | — |
Secondary
| Measure | Time frame |
|---|---|
| Parkinson's patients exhibit a stronger impairment for self initiated than externally triggered movements. | — |
Countries
Germany
Contacts
Public ContactFabienne Jung
Uniklinik Köln, AG für Bewegungsstörungen und Tiefe Hirnstimulation
Outcome results
None listed