F32.0 F32.1 F33.0 F33.1
Conditions
Interventions
Group 1: High-intensity Endurance training (twice weekly over 12 weeks ca. 60 minutes of moderate to high intensity), subsequently: cognitive behavioral therapy (twice weekly over 12 weeks, 50 minutes
Sponsors
Department Sport- und Gesundheitswissenschaften, Sozial- und Präventivmedizin, Universität Potsdam
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The study is conducted with 18- to 65- years old, as physical healthy diagnosed ambulant psychotherapy patients with the main diagnosis of a mild to moderate depressive episode diagnosed according to ICD-10 (F32.0, F32.1), which can also occur in the context of a recurrent depressive disorder (F33.0, F33.1). The presence of a major depressive episode is assured by creating structured clinical interview I for DSM - IV (SCID I) ; Axis I: mental disorders, depression section. The healthy control group (18-65 years old). Subjects of the healthy control group are 18-65 years old and have no major depressive disorder.
Exclusion criteria
Exclusion criteria: Following exclusion criteria are applied: current severe depressive episode with and without psychotic symptoms (F32.2, F32.3, F33.2 or F33.3), current borderline or dissocial personality disorder, acute suicide risk, current or lifetime schizophrenia spectrum disorder, delusional disorders (F2x.x), bipolar affective disorder (F31.x), current dependence (alcohol, heroin, amphetamine, cocaine), minimum period of rest 12 month, current severe neurological diseases and illnesses of central nervous system, severe chronic obstructive pulmonary disease (COPD), coronary heart disease, cardiac insufficiency, anaemia, body mass index > 35 or 50mg per day, neuroleptics with a dose of > 30% of the maximum daily dose, regular endurance training (more than two times per week for 45min).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depressive symptoms measured via self rating (Beck Depression Inventory, BDI) and external rating (Hamilton Rating Scale for Depression, HAM-D) from baseline to follow-up (t1: baseline, t2: after exercise therapy respectively waiting period, t3: after psychotherapy, t4: follow up) . | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain-derived neurotrophic factor (BDNF) levels are measured taking serum samples (t1-t2 before and after exercise electrocardiogram (ECG) and t3). In functional magnetic resonance tomography (fMRT) blood-oxygen-level-dependent (BOLD) signal is measured during working memory-, reward learning- and emotion regulation tasks (t1-t3). Self-efficacy measured via self rating (general self-efficacy scale, GSE)(t1-t4), Emotion-Regulation measured via self rating (emotion-regulation questinnaire, ERQ)(t1-t4), current physical activity measured via self rating (international physical activity questionnaire short form, IPAQ-SF)(t1-t4). Cognitive abilities such as working memory and inhibiton are measured via neuropsychological tests (digit span, digit symbol, stroop-task, verbal learning and memory test, VLMT)(t1-t4). Psychological distress measured via self rating (brief symptom inventory, BSI)(t1-t4), dysfunctional attitudes measured via self report (dysfunctional attitude scale, DAS)(t1-t4), pain intensity measured via self-rating (visual analogue scale)(t1-t4), disability related to pain measured via self rating (pain disability index, PDI)(t1-t4), basic psychological needs of relatedness, competence and autonomy measured via self rating (basic psychological need satisfaction and frustration scale, BPNSFS)(t1-t4), the atmosphere of health care in exercise training (t1-t2) and psychotherapy (t2-t3) is measured via self rating (health care climate questionnaire, HCCQ); physical fitness is measured during exercise ECG to calculate the maximum uptake of oxygen (VO2max.) (t1-t2) and blood-samples are taken to identify lactate (t1-t2). Cortisol level will be measured via saliva samples (24h)(t1-t3). | — |
Countries
Germany
Contacts
Public ContactAndreas Heißel
Universität Potsdam, Department Sport- und Gesundheitswissenschaften, Sozial- und Präventivmedizin
Outcome results
None listed