I25.13
Conditions
Interventions
Group 1: In patients with the need for coronary bypass surgery EDTA blood (plasma) is taken at the following times:
a. before connecting to the extracorporeal circulation (after opening the pericardiu
Sponsors
Universitätsklinik für Herz- und Thoraxchirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Coronary of extracorporeal circulation - Age> 18 years - Written consent
Exclusion criteria
Exclusion criteria: - Pre-existing rheumatic or chronic infectious disease (such as systemic lupus erythematosus, ANCA-positive vasculitis, rheumatoid arthritis, etc.) - Certain medications (cortisol, immunosuppressants, ongoing oncological therapy) - major surgery in the last 3 months - renal insufficiency stage 3 or higher (GFR <60ml / min)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of angiopoietin-1 and -2 as well as other inflammatory and endothelial marker | — |
Secondary
| Measure | Time frame |
|---|---|
| - Vital and laboratory values of the first 72h - fluid balance of the first 72 hours - Katecholamindosen the first 72h - organ dysfunction (Sequential Organ Failure Assessment [SOFA] and other scores) - consumption of blood products - hospital stays and intensive care hospital - survival - Quality of Life | — |
Countries
Germany
Contacts
Public ContactJohannes Hadem
Universitätsklinik für Herz- und Thoraxchirurgie
Outcome results
None listed