Effect of cerebral oximetry and minimized extracorporeal circulation on cognitive dysfunction after coronary bypass in patients at high risk of cerebrovascular events

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00008853

Enrollment

100

Registered

2015-07-20

Start date

2015-06-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.13

Interventions

Group 1: Group A: 50 patients with coronary heart disease (CHD), diabetes mellitus and / or chronic renal failure and need for coronary artery bypass graft received intraoperative NIRS with the goal o

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Written authorization of the study participant - Age> 18 years - Coronary with or without cardiopulmonary bypass (CPB) - Type 2 diabetes and / or renal impairment (GFR = 35% and <70% and / or left ventricular ejection fraction of <= 35%

Exclusion criteria

Exclusion criteria: Lack of written consent - Pregnancy - aortic surgery - stenosis of the carotid artery > 70% - Documented dementia - state after stroke - Lack of knowledge of the German language - Lack of possibility of follow-up studies - Pacemakers or other electrical implants - Claustrophobia (Ban Reason for MR subanalysis) - Coronary (possible reason for exclusion of the MR sub-analysis). This will be decided on an individual basis according to the specifications of the stent manufacturer.

Design outcomes

Primary

Measure	Time frame
Statistically significantly lower postoperative deterioration of neurocognitive function compared with the control group Test methods used: - MoCA (Montreal Cognitive Assessment) - Rey-figure / figure Taylor - CVLT-k (California Verbal Learning Test - short) - TMT A and B - Boston Naming Test (BNT) -. Short form according Th Merten (2004) - Regensburger word liquid test (RWT) - Digit Span forward and backward - Block span	—

Measure

Time frame

Statistically significantly lower postoperative deterioration of neurocognitive function compared with the control group Test methods used: - MoCA (Montreal Cognitive Assessment) - Rey-figure / figure Taylor - CVLT-k (California Verbal Learning Test - short) - TMT A and B - Boston Naming Test (BNT) -. Short form according Th Merten (2004) - Regensburger word liquid test (RWT) - Digit Span forward and backward - Block span

—

Secondary

Measure	Time frame
- Subclinical, morphological cerebrovascular events compared to baseline based MRI - Intraoperative measures to improve cerebral oxygenation - Duration of hospitalization - Duration intensive stay - Prevalence delirium - Biometric data and vital signs - Euro Core and Simplified Acute Physiology Score (SAPS) III - Hospital mortality	—

Countries

Germany

Contacts

Public ContactJohannes Hadem

Universitätsklinik für Herz- und Thoraxchirurgie

johannes.hadem@med.ovgu.de+49-391-6714132

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026