I25.9
Conditions
Interventions
Group 1: A: Individualized heparin management with assumed constant distribution volume (calculated blood volume rom body heigth, weight and gender and filling volume of extracorporeal circulation)
B
Sponsors
Universitätsklinikum Ulm, Kliniken am oberen Eselsberg
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Isolated coronary artery disease which can be operated on with conventional extracorporeal circulation 2. At least three significantly diseased and graftable targets (at least 1,5 mm diameter in angiogram)
Exclusion criteria
Exclusion criteria: 1. Emergency patients 2. Inborn or acquired bleeding/clotting tendency (platelet inhibitng medication allowed) 3. Liver disease, gastrointestinal disease with increased risk of bleeding 4. Left ventricular function 85 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Dose of Protamine (depending on inclusion of actual volume balance) after weaning from extracorporeal circulation 2. Significant differences in TAT and D-dimer (depending on usage of pericardial fluids) pre-protamine and at 0,6 and 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. drainage loss at 12 and 24 hours 2. Usage of blod and blood products up to 72 hours postoperatively 3. Common clinical and laboratory parameters during postoperative hospital treatment | — |
Countries
Germany
Contacts
Public ContactHagen Gorki
Univeristät UlmKlinik für Herz-, Thorax- undGefäßchirurgie
Outcome results
None listed