healthy volunteers
Conditions
Interventions
Group 1: Single oral dose of 1 mg resveratrol/kg body weight administered in a capsule
Sponsors
Max Rubner-InstitutBundesforschungsinstitut für Ernährung und Lebensmittel
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Healthy women and men (18-65 years old), BMI 20 – 30 kg/m2; no intake of antibiotics within the last 3 monts, no intake of laxatives or other drugs which may influence the intestinal system within the last 3 month; test persons which signed the agreement letter for the participation of this study.
Exclusion criteria
Exclusion criteria: Intake of antibiotics within the last 3 months, intake of laxatives or other drugs which may influence the intestinal system within the last 3 month; participants with serious diseases affecting the resorption of nutrients, digestion, metabolisation or excretion, pregnancy or lactation, participants who have ingested dietary supplements or drugs within the last 3 monts which may effect the parameters investigated in this study; participants which are expected to not behave compliant, participants with known allergies against RES or intolerance of food of which RES can be extracted, participants who are institutionalized due to an administrative order or court order by a court or a governmental order, participants who did not sign the agreement letter for participation of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the concentration of resveratrol (RES) and its microbial metabolites in urine (48-h- urine collection) and blood samples (of a subgroup of 12 participants) before and after (1.5, 24 and 48 hours) oral uptake of RES to identify the importance of RES microbial metabolites. Another aim of this study is the isolation and characterisation of lunularin-producing bacterial strains isolated from human fecal samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| Another aim of this study is the investigation, whether a single oral uptake of RES shows acute effects on selective parameters of the immune System (phagocytosis and respiratory burst, cytokine response of ex-vivo mitogen-activated peripheral blood mononuclear cells, cytolytic activity of natural killer cells (using cytometric bead array, CBA )). Moreover, it will be investigated if RES and its metabolites can be detected both from venous blood samples and from dried blood spots with capillary blood. | — |
Countries
Germany
Contacts
Public ContactAnita Kriebel
Max Rubner-Institut; Bundesforschungsinstitut für Ernährung und Lebensmittel
Outcome results
None listed