I10.9
Conditions
Interventions
Group 1: Therapy Arm:
24-hour blood pressure measurements and automated office-blood-pressure (RR) measurements are taken before the intervention (baseline).
After patient approval, therapy is perform
Sponsors
Klinikum der Universität München, Campus Großhadern
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: • Patient with therapy-resistant type. Hypertonicity (syst. RR> 140 mmHg despite optimized therapy with = 3 antihypertensive drugs of different classes - state of the art over 3 months), • Diagnosis of the therapy-resistant type. Hypertension by a specialist in nephrology / high-pressure ambulance takes place incl. Advice on all alternative therapy methods • GFR> 45 ml / min / 1.73 m² Pat. With refractory hypertension at Z.n. ineffective catheter-directed RDN
Exclusion criteria
Exclusion criteria: • patients with secondary hypertension (e.g., renoparenchymatous hypertension, NAST, primary hyperaldosteronism, pheochromocytoma, sleep apnea syndrome) • Stenosing heart valve disease • Z.n. Myocardial infarction, unstable angina pectoris, cerebrovascular event within the last 6 months prior to enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The procedure leads to a permanent lowering of blood pressure compared to the control group (state of the art antihypertensive medication plus sham treatment). | — |
Secondary
| Measure | Time frame |
|---|---|
| • Permanent reduction of antihypertensive medication in patients with refractory hypertension compared to sham control • Compared to catheter-guided radiofrequency ablation, the procedure is simpler, faster, less expensive, and feasible for patients with a contraindication to RFA. | — |
Countries
Germany
Contacts
Public ContactChristel Besseler
Klinik und Poliklinik für Radiologie Klinikum der Universität München Campus Großhadern
Outcome results
None listed