Evaluation of novel markers for early detection of colorectal cancer

Conditions

C18 C19 C20

Michael Hoffmeister, Teresa Seum, Leopold Ludwig, Hermann Brenner

Clinical Gastroenterology and Hepatology2025-05-202 citations

10.1016/j.cgh.2025.04.027

Colonoscopy-Ascertained Prevalence of Advanced Neoplasia According to Fecal Hemoglobin Concentration in a Large Cohort of Fecal Immunochemical Test–Negative Screening Participants

Tobias Niedermaier, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister, Hermann Brenner

Annals of Internal Medicine2023-11-018 citations

10.7326/m23-1358

Interventions

Group 1: Observational Study with diagnostic intervention: the participants will be asked to donate a blood sample, 2 native stool samples and to perform 2 FIT and one Hemoccult test.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: participants in screening colonoscopy, informed consent

Exclusion criteria

Exclusion criteria: Inadequate knowledge of German, diagnostic colonoscopy, missing informed consent document

Design outcomes

Primary

Measure	Time frame
sensitivity and specificity of tests for the detection of advanced colorectal neoplasia	—

Secondary

Measure	Time frame
sensitivity and specificity of tests for the detection of colorectal carcinomas, advanced colorectal adenomas and other colorectal adenomas	—

Countries

Germany

Contacts

Public ContactJason Hochhaus

Deutsches Krebsforschungszentrum Heidelberg

j.hochhaus@dkfz.de06221421329

Outcome results

None listed