Neuronal plasticity of network topography in parkinson disease through LSVT-BIG therapy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00008732

Enrollment

Registered

2015-11-09

Start date

2015-09-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20

Interventions

Group 1: 20 patients receive LSVT-BIG therapy for 4 weeks (4x 60 min per week). Before and after the 4 weeks of therapy, half of them gets an rs-fMRI. All of them need to do a gangway-test ( three tim

Eligibility

Sex/Gender

All

Age

25 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients (Gender masculin or feminin) with the clinical diagnosis of an idiopathic parkinson syndrome. Age between 25 and 80 years. Good german language skills. Patients need to be capable to consent and have to sign a consent.

Exclusion criteria

Exclusion criteria: Patients, who suffer under another disease that affects their cognition (for example vascular disease, Tumor). Patients with strong depression (BDI over 29 points) and/or dementia (Panda 20 %) in the last 6 months. Pulmonary embolism, myocardial infarct, endocarditis in the last 3 months. Haemodynamic relevant stenosis of aortic valve and/or mitralic valve.

Design outcomes

Primary

Measure	Time frame
Improvement of non-motor-symptoms before and after the physiotherapy. Evaluation through the NMS-Score in the week before and after the therapy. Socre is taken in the week before and after the physiotherapy.	—

Secondary

Measure	Time frame
- Motoric functions (UPDRS III), video hast to be recorded baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. Evaluation by two persons. - Psychometric functions (BDI-2, AES, PANDA and MMST). Questionnaires have to be answered baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. -PDQ-39 evaluates quality of life. Questionnaire has to be answered baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. - ReHo/Fc rs-fMRI with the focus on the motoric network activity and core theme on the premotoric cortex, SMA, primary sensomotoric cortex, putamen and cerebellum, rs-fMRI has to be done in the week before and after the physiotherapy at the same time.	—

Measure

Time frame

- Motoric functions (UPDRS III), video hast to be recorded baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. Evaluation by two persons. - Psychometric functions (BDI-2, AES, PANDA and MMST). Questionnaires have to be answered baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. -PDQ-39 evaluates quality of life. Questionnaire has to be answered baseline up to 7 days before the physiotherapy starts and follow-up within the 7 days after the end of physiotherapy. - ReHo/Fc rs-fMRI with the focus on the motoric network activity and core theme on the premotoric cortex, SMA, primary sensomotoric cortex, putamen and cerebellum, rs-fMRI has to be done in the week before and after the physiotherapy at the same time.

—

Countries

Germany

Contacts

Public Contactcand. med. Fabian Schaible

Neurologie Uniklinik Köln

fabian.schaible@uk-koeln.de015735141244

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 16, 2026