Characterization of reward-processing, resting-state metabolism, social cognition, social comparison based motivation between patients with therapy-resistant OCD and substance abuse disorder and healthy participants

Characterization of reward-processing, resting-state metabolism, social cognition, social comparison based motivation between patients with therapy-resistant OCD and substance abuse disorder and healthy participants - CoRaS

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00008583

Enrollment

Registered

2015-06-18

Start date

2015-10-27

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F42 F10.2

Interventions

Group 1: 6 months follow-up after dbs - On Assesement of: - psychopathological questionnaires (specific for disorder e.g. YBOCS for OCD und AUDIT for substance abuse disorder) - resting state metab

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: • Age 18-65 • Assessed substance abuse disorder or OCD (ICD-10 or DSM-IV criteria) • Patient approves to be evaluated • Disorder was treated with a DBS • Patients have to be capable to give consent • Written informed consent

Exclusion criteria

Exclusion criteria: • paranoide-hallucinatory episode in the last 6 months • current depressive disorder • current organic or pharmacological psychotic episode • pregnancy or breast-feeding • suicidal tendencies or violent behaviour in the last six weeks • serious or instable physical disease or brain tumor • clinical relevant internal or neurological disease • Withdrawal of informed consent • FDG-PET contradiction

Design outcomes

Primary

Measure	Time frame
Change of impulsivity will be assesed with a delay discounting paradigma which results in a k-parameter (a high k-paramater indicates high impulsivity and a low k-parameter indicates low impuslvity) and the the baseline k-parameter (assesment before operation) will be compared to the acute effects of the on/off condition.	—

Secondary

Measure	Time frame
Change of resting-state metabolism will be assessed with FDG-PET. Effects of modulation shall be visualised by comparing the on and off condition.	—

Countries

Germany

Contacts

Public ContactCanan Peisker

Uniklinik KölnKlinik für Psychiatrie und Psychotherapie

canan.peisker@uk-koeln.de022147898843

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026