F34.1 F31.3 F31.4 F31.5 F32 F33
Conditions
Interventions
Group 1: patients with major depression, visit 1: PET scan of 120 minutes duration with (-)-[18F]Fluspidine (300 +/- 10% MBq) splitted in 2 scans of 90 respectively 30 minutes within one day.
visit 2
Sponsors
Universität Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - age between 18 and 65 years - caucasian - without psychotropic medication for at least 2 weeks before PET - patients with depressive disorder and healthy controls
Exclusion criteria
Exclusion criteria: - significant cerebral lesions - stroke, cocussion, severe subcortical arteriosclerotic encephalitis, multiple sclerosis, brain tumor, dementia, Parkinsons disease - pregnancy, breast-feeding - legally incopetent persons - impaired medical conditions (instable angina pect oris, recent mycardial infarct, malignant disease) - severely impaired sight or hearing abilitiy - contraindications for MRT (metal implants e.g.) for healty controls: participation in a study for diagnostic or therapeutic purpose by means of ionising radiation within the last 10 years,. if an effective radiation dose of more than 10 mSv can be expected
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Examination of the central sigma-1-receptor availibility in patients with major depressive disorder compared to healthy controls using (-)-[18F]Flusipidine and PET | — |
Secondary
| Measure | Time frame |
|---|---|
| - correlation analyses between neuro-psychometric scales, genetic variables and PET-data - data of safety and tolerability of (-)-[18F]Fluspidine - development of a kinetic model for analysis of (-)-[18F]Fluspidine PET data | — |
Countries
Germany
Contacts
Public ContactFranziska Zientek
Univesitätsklinikum Leipzig Klinik und Poliklinik für Nuklearmedizin
Outcome results
None listed