G43.0 G43.1
Conditions
Interventions
Group 1: High-intensity interval training: running training 2x/week for 12 weeks, with 4x4 minute intervals at 90% maximum heart rate with 3 minutes active recovery in between intervals at 70% maximum
Sponsors
Departement für Sport, Bewegung und GesundheitUniversität Basel
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Diagnosis of migraine by an experienced neurologist according to the International Classification of Headache Disorders, second edition (ICHD-II).
Exclusion criteria
Exclusion criteria: (a) current medical preventive therapy (patients can be included if preventive medication was stopped at least 8 weeks before study entry), (b) other internal or neurological diseases, (c) regular exercise experiences (>2h of moderate to vigorous exercise per week) within the last 6 months, (d) patients with coronary heart disease, (e) chronic heart failure, (f) hypertension, (g) current use of antihypertensive medication or (h) peripheral arterial disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of days with headache will be measured using a headache diary during run-in, intervention and follow up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache intensity and number of days with migraine is measured during run-in, intervention and follow up using a diary. Headache associated disability (MIDAS questionnaire), cerebral (fMRI), endocrine (serum B-Endorphin), kognitive (Mini-Mental-State test, Trail Making Test, SWITCH Test, Tower of London Test, Regensburger Wortflüssigkeitstest, Frontal Assessment Batttery), and vascular function (retinal vessel diameter, SVA-T), cardio-respiratory fitness (spiroergometry), pain thresholds (thermode), and quality of life (WHO-QoL, BREF) are measured before and after the intervention phase. | — |
Countries
Switzerland
Contacts
Public ContactGavin Brupbacher
Departement für Sport, Bewegung und GesundheitUniversität Basel
Outcome results
None listed