F32.2 F33.2
Conditions
Interventions
Group 1: paired associative stimulation (PAS) after one night of therapeutic sleep deprivation in patients with major depressive disorder
PAS consists of 200 pairs of electrical and transcranial stimuli at a rate of 0.25 Hz with an interstimulus interval of 25 ms (duration ~ 13 min). Peripheral electrical stimulation is applied to the m
Sponsors
Universitätsklinikum FreiburgKlinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: • Ages = 18 = 65 • Ability to provide informed consent • normal or corrected-to-normal vision • Absence of any exclusion criteria • Major depressive disorder (ICD-10: F32.2 and F33.2) • Score of =15 on the 21-item Hamilton Rating Scale for Depression (HAMD)
Exclusion criteria
Exclusion criteria: • Neurological disorders including epilepsy, history of brain injury, encephalitis, or any organic brain syndrome • metallic implants • present pregnancy • DSM-V axis I disorder (lifetime) apart from major depression, such as schizophrenia, schizoaffective disorder, any non-bipolar psychotic disorder, bipolar disorders, primary anxiety or obsessive compulsive disorder, mental retardation, signs of impaired cognitive functioning • Lifetime history for drug/alcohol dependence, or drug/alcohol abuse within the past year • Medication with any anxiolytic or antipsychotic drug, except antidepressants for patients • Medical conditions including severe cardiac, liver, kidney, endocrine (e.g., diabetes), hematologic disorders (e.g., porphyria or any bleeding abnormalities), other impairing or unstable medical condition or impending surgery • Primary sleep disorders diagnosed according to DSM-V criteria. • Inability to read or understand the study forms and agree to informed consent. • Irregular sleep schedules associated with shift work, frequent travel, or personal preference as indicated by weekly variation of >3 hours in bed time or wake time, or sleep duration 10 hours per night. • Left-handedness • Acute suicidality • Psychotic features of MDD • Excessive use of caffeine (>300 mg or three cups of coffee per day). • Excessive smoking (>10 cigarettes/day).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| increase of the mean motor evoked potential (MEP) amplitude 30 min after paired associative stimulation (PAS) compared to baseline in the morning after one night of sleep deprivation | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG theta power of the wake-EEG, mean reaction time in the Psychomotor Vigilance Task (PVT), recall performance in a declarative memory task (word-pair associates), BDNF genotype, BDNF serum level and salivary cortisol levels, transcranial magnetic stimulation (TMS) responses in non-responders to sleep deprivation. All examinations will take place in the morning after one night of therapeutic sleep deprivation. | — |
Countries
Germany
Contacts
Public ContactChristoph Nissen
Universitätsklinikum FreiburgKlinik für Psychiatrie und Psychotherapie
Outcome results
None listed