Histomorphological Study of the Intraepidermal Nerve Fiber Density (IENFD) and Composition of the Dermal Inflammatory Infiltrate in Itching Dermatoses, Itching Systemic Diseases and Itch Without Inflammatory Skin Lesions

Histomorphological Study of the Intraepidermal Nerve Fiber Density (IENFD) and Composition of the Dermal Inflammatory Infiltrate in Itching Dermatoses, Itching Systemic Diseases and Itch Without Inflammatory Skin Lesions - SST-PR-6-2007

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00008006

Enrollment

270

Registered

2015-05-20

Start date

2012-07-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

L28.1 L29.9

Interventions

Group 1: Determination of intraepidermal nerve fiber density and inflammatory infiltrate in atopic dermatitis, prurigo nodularis, nephrogenic Pruritus, cholestatic Pruritus, diabetogenic pruritus, bra

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with atopic dermatitis, prurigo nodularis, nephrogenic Pruritus, cholestatic Pruritus, diabetogenic pruritus, brachioradial pruritus, small fiber neuropathy, pruritus on non-inflammatory skin and normal skin

Exclusion criteria

Exclusion criteria: pregnancy, breastfeeding, wound healing disorders or tendency to keloid

Design outcomes

Primary

Measure	Time frame
Determination of intraepidermal nerve fiber density and inflammatory infiltrate in atopic dermatitis, prurigo nodularis, nephrogenic Pruritus, cholestatic Pruritus, diabetogenic pruritus, brachioradial pruritus, small fiber neuropathy, pruritus on non-inflammatory skin and normal skin	—

Secondary

Measure	Time frame
Characterisation of the inflammatory infiltrate in prurigo nodularis patients via immunohistochemiistry and FACS-analysis Comparison of the intraepidermal nerve fiber density in lesional, non-lesional, interlesional and recovered skin in prurigo nodularis.	—

Countries

Germany

Contacts

Public ContactSonja Ständer

Kompetenzzentrum chronischer Oruritus (KCP) und Klinik für Hautkrankheiten

juckreizambulanz@ukmuenster.de0251-8357470

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026