Skip to content

Buffering effects of non-invasive vagus nerve stimulation on stress-induced psychobiological alterations: a placebo-controlled trial in normal-weight and obese subjects

Buffering effects of non-invasive vagus nerve stimulation on stress-induced psychobiological alterations: a placebo-controlled trial in normal-weight and obese subjects

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00007991
Enrollment
200
Registered
2015-04-07
Start date
2014-04-14
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stress E66.90 E66.91

Interventions

Group 1: Two hundred participants are investigated. One hundred with a BMI between 18.5 and 25 and 100 with a BMI between 28 and 40. The groups are build as follows: I. Two groups undergo a non invas

Sponsors

Universität ZürichPsychologisches InstitutKlinische Psychologie und Psychotherapie
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 38 Years

Inclusion criteria

Inclusion criteria: 1. Male sex 2. Age range from 18-38 years 3. Good knowledge of the German language 4. BMI between 18.5 and 25 kg/m2 or between 28 and 40 kg/m2

Exclusion criteria

Exclusion criteria: 1. Acute and/or chronic somatic diseases 2. Mental disorders. 3. Known sensitivity of the head to cold, pressure, and draft 4. Medication intake or substance abuse in the last two months 5. Consumption of psychedelic drugs in the last four weeks 6. Excessive consumption of alcohol (more than 2 beverages p.d.) 7. Consumption of tobacco (more than 10 cigarettes p.d.) 8. Bodybuilding (more than 3 hours a week) 9. Wearing pacemakers, defibrillators, and cochlear and/or metal implants 10. Blood donation or significant blood loss (due to accident or surgery) in the last three months 11. Long-distance flight in the past two weeks 12. Shift work 13. Participation in a previous stress study or concomitant participation in other intervention studies

Design outcomes

Primary

MeasureTime frame
Outcome: Stress reactiviy Messung: physiological measures (hormones: cortisol, testosteron, progestoren, estradiol, inflammtion: cytokines, C-reactive protein, metabolic: Insulin, glucose, cardio vascular: heart rate, heart rate variability) Time points: before, during and after stress tests

Secondary

MeasureTime frame
Psychological tests: Empathy, implicite motives, interoception and further questionnaires. Further physiological measures: Waist-to-Hip, resting metabolic rate, bio impedance

Countries

Switzerland

Contacts

Public ContactNiclà Lozza

Universität ZürichPsychologisches InstitutKlinische Psychologie und Psychotherapie

n.lozza@psychologie.uzh.ch0041 44 635 73 69

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026