Subjective Cognitive Decline (SCD)
Conditions
Interventions
Group 1: The study is a sub-study of DRKS00007966 and raises the glucose metabolism and amyloid deposits in the brain using PET. Both investigations are carried out twice, at baseline and after 24 mon
Sponsors
Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Additional inclusion criteria to the DELCODE main study: -Subjects with SCD (onset > 6 months to < 5 years) without objective cognitive deficits -Written informed consent to participate in longitudinal PET scans with 18F-Florbetaben and 18F-FDG (maximum two scans per modality) within an interval of two years -Availability of structural MRI data
Exclusion criteria
Exclusion criteria: Additional exclusion criteria to the DELCODE main study: -Lack of capability to give informed consent -Subjects exposed within the last 10 years to radioactive substances or ionizing radiation for research- or treatment purposes (§88 Abs. 2, Federal radiation protection regulation) -Subjects with blood glucose values >140 mg/dl (refers only to 18F-FDG PET) measurement will be postponed until glucose levels are stable -Insulin-dependent diabetes -Anamnestic evidence for severe renal and liver dysfunction -MR evidence for relevant structural abnormalities -Lack of ability to lie still for 30-40 minutes (i.e. expected scan duration)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systematic functional characterisation of SCD subgroups based on biomarker profiles | — |
Countries
Germany
Contacts
Public ContactProjektmanagement
Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Outcome results
None listed