Removal of cytokines during cardiac surgery

Removal of cytokines during cardiac surgery - RECCAS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00007928

Enrollment

Registered

2015-08-03

Start date

2015-01-26

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative inflammatory responseOrgan failure

Interventions

Group 1: Study group - Use of intraoperative haeoadsorption with CytoSorb Group 2: Control group - Standard of care

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: - Adult patients > 65 years undergoing cardiac surgery with CPB-duration > 90 min - Written informed consent

Exclusion criteria

Exclusion criteria: - Age < 65 years - Missing informed consent - Planned CPB temperature < 32°C - Emergency surgery - Previous renal replacement therapy - Preexisting kidney disease not requiring RRT (GFR < 30 mL/min) - Prior kidney transplant - Application of contrast medium on the day of surgery - Immunosuppressive therapy or long-term therapy with corticosteroids - Acute infective endocarditis - AIDS with a CD4 count of < 200/µL - Participation in another clinical intervention trial

Design outcomes

Primary

Measure	Time frame
Reduction of IL6 by intraoperative haemoadsorption (Time points: baseline, intraoperative, admission on ICU, day 1 and day 2)	—

Secondary

Measure	Time frame
- Length of ICU and hospital stay - ICU and hospital mortality - Number of complications (e. g. pneumonia, delirium, organ failure, infections, renal failure) - Incidence of acute kidney injury (according to AKIN criteria) - Duration of RRT - SOFA-score - Kinetics of different blood and urine markers (IL-6, IL-2, IL-8, IL-10, TNF-alpha, C3a, free haemoglobin, haptoglobin, myoglobin, fibrinogen ICG-PDR, syndecan-1, heparan-sulphate and hyaluronan, [TIMP-2]x[IGFBP7]) Time points: baseline, intraoperative, admission on ICU, day 1 and day 2 - haemodynamics (arterial pressure, heart rate, cardiac output, preload, syst. vascular resistance, extravascular lung water, doses of catecholamines) Time points: baseline, intraoperative, admission on ICU, day 1 and day 2) - duration of mechanical ventilation, respiratory function	—

Measure

Time frame

- Length of ICU and hospital stay - ICU and hospital mortality - Number of complications (e. g. pneumonia, delirium, organ failure, infections, renal failure) - Incidence of acute kidney injury (according to AKIN criteria) - Duration of RRT - SOFA-score - Kinetics of different blood and urine markers (IL-6, IL-2, IL-8, IL-10, TNF-alpha, C3a, free haemoglobin, haptoglobin, myoglobin, fibrinogen ICG-PDR, syndecan-1, heparan-sulphate and hyaluronan, [TIMP-2]x[IGFBP7]) Time points: baseline, intraoperative, admission on ICU, day 1 and day 2 - haemodynamics (arterial pressure, heart rate, cardiac output, preload, syst. vascular resistance, extravascular lung water, doses of catecholamines) Time points: baseline, intraoperative, admission on ICU, day 1 and day 2) - duration of mechanical ventilation, respiratory function

—

Countries

Germany

Contacts

Public ContactAndreas Baumann

BG Universitätsklinikum Bergmannsheil

andreas.baumann@bergmannsheil.de0234-3023496

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 13, 2026