Immunohistological investigation of the potential role of pro-inflammatory biomarkers and revascularisation in the pathogenesis of ischemia reperfusion injury

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00007906

Enrollment

Registered

2015-03-19

Start date

2008-04-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischmemia/reperfusion injury

Interventions

Group 1: Tissue biopsies of human free flap tissue prior to and five days after ischemia/reperfusion injury.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients undergoing reconstructive surgery procedures with free microvascular tissue transfer.

Exclusion criteria

Exclusion criteria: Underlying inflammatory diseases, elevated baseline values of circulating plasma CRP. Prior free flap failure.

Design outcomes

Primary

Measure	Time frame
Detection of conformational changes of C-reactive protein in human tissue samples undergoing ischemia/reperfusion	—

Secondary

Measure	Time frame
Detection of accumulation of cytokines and C-reactive protein in postischaemic tissue, correlating with the localized tissue inflammation.	—

Countries

Germany

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026