Longitudinal neuropsychological and neuroradiological investigation of cognitive Impairment in early versus late MS and its correlation to hippocampal dysfunction (HIPPOCOMS2)

Longitudinal neuropsychological and neuroradiological investigation of cognitive Impairment in early versus late MS and its correlation to hippocampal dysfunction (HIPPOCOMS2) - HIPPOCOMS II

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00007905

Enrollment

Registered

2015-03-24

Start date

2015-05-04

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G35

Interventions

Group 1: Early MS (EMS, N=25): Patients that participated in the previous study "Hippocoms" (in the year 2011) and that had at that time a disease duration of < 2 years. Patients in both groups (EMS,

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion in previous study (Hippocoms I, 2011) Written and oral informed consent

Exclusion criteria

Exclusion criteria: MS relapse within the past 4 weeks Steroide treatment within last 4 weeks Exclusion criteria for MRI, e.g. large tattoos, non-removeable piercings, cardiac pacemaker, severe renal insufficiency ((eGFR 0,2 (in one or two eyes) alcohol abuse pregnancy

Design outcomes

Primary

Measure	Time frame
Differences (between and within groups, including baseline data from the 2011 “Hippocoms” study) in the cognitive performance in the following tests: • Symbol Digit Modalities Test (SDMT) • Rey auditory verbal learning test (AVLT) • ROC figure (copy, delayed recall) • Alertness (TAP) • Divided attention (TAP) • Mental flexibility (TAP) • Diagnosticum for cerebral damage (DCS Wolfram) • Verbal learning test (VLT) • Nonverbal learning test (NVLT) Differences (between and within groups, including baseline data from the 2011 “Hippocoms” study) in the following MRI parameters: • whole brain volume • cortical thickness • hippocampal volume • T1 lesion load • T2 lesion load • number of active lesions Differences (between and within groups, including baseline data from the 2011 “Hippocoms” study) in the parameter estimates of the processing capacity assessed by NTVA (neural theory of visual attention): • C • K • t0 • my	—

Measure

Time frame

Differences (between and within groups, including baseline data from the 2011 “Hippocoms” study) in the cognitive performance in the following tests: • Symbol Digit Modalities Test (SDMT) • Rey auditory verbal learning test (AVLT) • ROC figure (copy, delayed recall) • Alertness (TAP) • Divided attention (TAP) • Mental flexibility (TAP) • Diagnosticum for cerebral damage (DCS Wolfram) • Verbal learning test (VLT) • Nonverbal learning test (NVLT) Differences (between and within groups, including baseline data from the 2011 “Hippocoms” study) in the following MRI parameters: • whole brain volume • cortical thickness • hippocampal volume • T1 lesion load • T2 lesion load • number of active lesions Differences (between and within groups, including baseline data from the 2011 “Hippocoms” study) in the parameter estimates of the processing capacity assessed by NTVA (neural theory of visual attention): • C • K • t0 • my

—

Secondary

Measure	Time frame
Prediction of cognitive changes (regression analysis) by baseline processing capacity (NTVA: C, K, t0, my) and by baseline MRI (brain volume, hippocampal volume, cortical thickness, t1 and t2 lesion load).	—

Countries

Germany

Contacts

Public ContactMartin Fischer

Fachkrankenhaus Hubertusburg gGmbH

martin.fischer@sanktgeorg.de+49 34364 62355

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026