Comparison of the cerebellum in adult very preterm infants versus term infants with 3 and 7 Tesla MRI- correlation with cognitive functions in young adulthood.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00007883

Enrollment

Registered

2015-03-09

Start date

2015-05-19

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

KOGNITIVEFUNKTIONSEINSCHRNKUNGEN P07.1

Interventions

Group 1: "group of preterm infants" (3 and 7 T MRI, neurologic examination, Ataxia-Rating Scale (SARA, 5th Ed. + INAS), intelligence scale (WAIS-IV), questionaire on life contentment (LFZ), blink refl

Eligibility

Sex/Gender

All

Age

18 Years to 25 Years

Inclusion criteria

Inclusion criteria: "group of preterm infants": born 24+0 - /= 37+0 weeks

Exclusion criteria

Exclusion criteria: chromosomal abnormalities, neurologic or psychiatric diseases, Epilepsia, intracranial hemorrhage > grade I or periventricular leucomalacia in neonatal period, special educational needs, claustrophobia, metal or active implants, fixed braces, drug or alcohol abuse, sedatives, breastfeeding, pregnant women or those who cannot exclude pregnancy, relative contraindications: tatoos, steel implants, intrauterine device, permanent make-up

Design outcomes

Primary

Measure	Time frame
Volume and structure /substructure of the cerebellum, visualization of lesions, visualization of dentate ncl.	—

Secondary

Measure	Time frame
neurologic examination, Scale for the Assessment and rating of ataxia (SARA, 5th ed.: 8 items: gait, stance, Sitting, speech disturbance, finger chase (dysmetria), nose-finger test (tremor), fast alternating hand movements (diadochokinesia), heel-shin slide), Inventory of Non-Ataxia Symptoms (INAS: Reflexes, Motor Symptoms, sensory Symptoms, opthalmological Findlings) Blinkreflexkonditionierung (Delay-Paradigma), blink reflex conditioning (Delay paradigma), Wechsler Adult Intelligence Test IV (3 IQ-scores: verbal IQ, perceptional reasoning IQ and general ability-IQ and 4 index scores: verbal comprehension, perceptual reasoning, working memory, processing speed), questionaire on life satisfaction (Fragebogen zur Lebenszufriedenheit, 10 items: Health, work, financial situation, leisure time, Partnership and marriage, Relationsship to children, own personality, sexuality, community, living) eyeblink-conditioning	—

Measure

Time frame

neurologic examination, Scale for the Assessment and rating of ataxia (SARA, 5th ed.: 8 items: gait, stance, Sitting, speech disturbance, finger chase (dysmetria), nose-finger test (tremor), fast alternating hand movements (diadochokinesia), heel-shin slide), Inventory of Non-Ataxia Symptoms (INAS: Reflexes, Motor Symptoms, sensory Symptoms, opthalmological Findlings) Blinkreflexkonditionierung (Delay-Paradigma), blink reflex conditioning (Delay paradigma), Wechsler Adult Intelligence Test IV (3 IQ-scores: verbal IQ, perceptional reasoning IQ and general ability-IQ and 4 index scores: verbal comprehension, perceptual reasoning, working memory, processing speed), questionaire on life satisfaction (Fragebogen zur Lebenszufriedenheit, 10 items: Health, work, financial situation, leisure time, Partnership and marriage, Relationsship to children, own personality, sexuality, community, living) eyeblink-conditioning

—

Countries

Germany

Contacts

Public ContactBritta Hüning

Universitätsklinikum Essen,Oberärztin und Prüfärztin der Klinik für Kinderheilkunde I, Neonatologie

ab-durch-die-roehre@uk-essen.de0201/723-5154

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026