Implicit and explicit learning and memory processes in acute hippocampal impairment: The role of stress

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00007874

Enrollment

Registered

2015-03-11

Start date

2013-08-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G45.4

Interventions

Group 1: Patients with a transient global amnesia, still in the acute episode at the time of study recruitment. Sequence of examinations: T0 (day 0): - physical examination - short structured neurop

DWI

FLAIR) - 3 salivary cortisol measurements: in ER, directly before MRI and after MRI T1 (day 1): - neuropsychological testing - stress questionnaires - MRI (resting state fMRI

fear conditioning fMRI

FLAIR

MR-Angio

3D-MP-RAGE) - 2 salivary cortisol measurements: directly before MRI and after MRI - after MRI SECPT or control procedure with warm water (randomized order), recording of blood pressure, heart rate and

DTI) - 2 salivary cortisol measurements: directly before MRI and after MRI - after MRI control procedure with warm water or SECPT (randomized order), recording of blood pressure, heart rate and saliva

3D-M

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Arm 1: - transient global amnesia - patient is still in the Episode Arm 2: - healthy control subject, no acute disease Both groups: - right-handed person - written consent to participate in the study

Exclusion criteria

Exclusion criteria: Arm 1: - episode of anterograde amnesia has already ended Both groups: - contraindication against MRI - taking cortisol preparations

Design outcomes

Primary

Measure	Time frame
Changes in brain networks measured with resting-state fMRI (T0, T1, T2), between the two groups and within the TGA Group (arm 1) over time	—

Secondary

Measure	Time frame
Group comparison between arm 1 and arm 2 concerning: - acute cortisol values and cortisol dynamic - cortisol day profile and dexamethasone suppression test - stress reactivity (SECPT and control procedure) - neuropsychological Parameters - stress scales - fear conditioning fMRI - DTI - hippocampus volumetry - further clinical, laboratory and MRI Parameters Descriptive statistics of the TGA group (arm 1): - Dynamics of the cortisol values in the acute Phase - neuropsychological characterization in the acute phase - number and localization of DWI changes	—

Measure

Time frame

Group comparison between arm 1 and arm 2 concerning: - acute cortisol values and cortisol dynamic - cortisol day profile and dexamethasone suppression test - stress reactivity (SECPT and control procedure) - neuropsychological Parameters - stress scales - fear conditioning fMRI - DTI - hippocampus volumetry - further clinical, laboratory and MRI Parameters Descriptive statistics of the TGA group (arm 1): - Dynamics of the cortisol values in the acute Phase - neuropsychological characterization in the acute phase - number and localization of DWI changes

—

Countries

Germany

Contacts

Public ContactMartin Griebe

Neurologische KlinikUniversitätsMedizin MannheimUniversität Heidelberg

griebe@neuro.ma.uni-heidelberg.de+496213832885

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026