F06.7
Conditions
Interventions
Group 1: -20 Subjects with MCI: 12-week cognitive-motor training
- 1 time weekly 120-135 min
Group 2: 20 subjects with MCI: without 12-week cognitive-motor training
Group 3: 21 healthy volunteers
Sponsors
Universitätsklinik für Neurologie
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: - MCI
Exclusion criteria
Exclusion criteria: - Probable dementia, - History of severe diseases such as stroke or psychiatric disease, - Treatment with antipsychotics and antidepressants, - The existence of a relevant depressive mode with a value above 13 by the Beck Depression Inventory - Unstable medical conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Episodic memory performance: At the beginning and at the end of the training phase is detailed neuropsychological testing by VLMT (Verbal learning and memory test) | — |
Secondary
| Measure | Time frame |
|---|---|
| - BDNF plasma levels by ELISA: At the beginning and at the end, and once after training - Identification of the hippocampus volume by MRI: at the beginning, after completion of the initial training period at 3 months and 6 months. - Test for Attentional Performance: Rey-Osterrieth figure, logo test number range and block span, Verbal Fluency, Boston Naming Test, Trail-Making Test A and B, TAP | — |
Countries
Germany
Contacts
Public ContactDaniel Bittner
Universitätsklinik für Neurologie
Outcome results
None listed