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Investigating the neurobiological stress response to pain in Adolescent Non-Suicidal Self-Injury

Investigating the neurobiological stress response to pain in Adolescent Non-Suicidal Self-Injury

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00007807
Enrollment
60
Registered
2015-02-13
Start date
2013-12-01
Completion date
Unknown
Last updated
2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-Suicidal Self-Injury F60.3

Interventions

Group 1: Assessment of pain sensitivity and physiological reactivity to a standardized cold pain stimulus in adolescents with non-suicidal self-injury. Group 2: Assessment of pain sensitivity and phys

Sponsors

Klinik für Kinder- und Jugendpsychiatrie, Zentrum für Psychsoziale Medizin, Universitätsklinikum Heidelberg
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
12 Years to 17 Years

Inclusion criteria

Inclusion criteria: adolescents with non-suicidal self-injur/ borderline personality disorder; age and sex matched healthy controls

Exclusion criteria

Exclusion criteria: Other major psychiatric disorders (e.g.schizophrenia), current episode of substance abuse, cardiovascular disease (e.g. hypertension)

Design outcomes

Primary

MeasureTime frame
Hypothalamic–Pituitary–Adrenal (HPA) axis assessed by saliva cortisol pre and post painful stimulation; autonomic nervous system response continuously assessed by heart rate and heart rate variability and blood pressure pre and post painful stimulation

Secondary

MeasureTime frame
The latencies to the first pain sensation (pain threshold) and to intolerable pain (pain tolerance) are measured with a stopwatch in seconds; pain intensity ratings are obtained using visual analogue scales and standardized questionnaires

Countries

Germany

Contacts

Public ContactMichael Kaess

Klinik für Kinder- und Jugendpsychiatrie, Zentrum für Psychsoziale Medizin, Universitätsklinikum Heidelberg

Michael.Kaess@med.uni-heidelberg.de+49 6221 566915

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 17, 2026