F32 K70-K77
Conditions
Interventions
Group 1: Vitamin D supplements (20,000 IU Dekristol p.o. daily for 7 days, thereafter weekly) for 6 months
Patients: with chronic liver disease and vitamin D deficiency with or without depression. We
Sponsors
Saarland University Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - men and women - over 18 years of age - chronic liver disease
Exclusion criteria
Exclusion criteria: - severe hepatic encephalopathy (CFF 2.7 mmol/l) or hypercalciuria (>8.0 mmol/d) with or without hyperparathyroidism (>65.0 pg/ml) - history of calcium-containing kidney stones - allergy or hypersensitivity to any of the supplement ingredients: peanuts, soy, gelatin - sarcoidosis - stage IV or V Chronic Kidney Disease - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes to depressive symptoms after 3 and 6 months of vitamin D supplementation, as assessed using the BDI-II instrument | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes to serum liver function tests (ALT, AST, AP, GGT, Bilirubin, Albumin) after 3 and 6 months, as assessed using standard clinical-chemical assays changes to bone density after 12 months, assessed using Dexa scans | — |
Countries
Germany
Contacts
Public ContactFrank Lammert
Saarland University Medical Center
Outcome results
None listed