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Cardiac wall stress determines ventricular ejection and filling rate

Cardiac wall stress determines ventricular ejection and filling rate - LAHN-III

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00007756
Enrollment
1000
Registered
2015-02-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I50 R06.0

Interventions

Group 1: It is aimed to examine potential influences of left ventricular wall stress on cardiac systolic ejection and diastolic filling. Therefore, it is intended to analyze data of patients who had b

Sponsors

Innere Medizin - Pneumologie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with heart failure or suspected cardiomyopathy

Exclusion criteria

Exclusion criteria: Implanted cardioverter/defibrillators, heart valve diseases more than moderate, implanted heart valve prothesis, severe kidney disease, malignancies

Design outcomes

Primary

MeasureTime frame
To assess a potential association between increased ventricular wall stress and a reduced ventricular peak ejection or peak filling rate. LV volumes, mass, peak ejection and filling rate are standard parameters and were assessed for clinical routine diagnostics (cardio-MR measurements). Based on LV volumes and mass, LV wall stress can be calculated by using a sphere-model. The method was previously validated. Additional measurements due to study reasons are not required. End-point: Analysis (among others by logistic regression) to examine wheter increased wall stress is associated with a reduced ventricular ejection or filling.

Secondary

MeasureTime frame
To assess a potential association between increased ventricular wall stress and an increased pulmonary pressure.

Countries

Germany

Contacts

Public ContactPeter Alter

Innere Medizin - Pneumologie

alter@uni-marburg.de+4964215866140

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026