G43.9
Conditions
Interventions
Group 1: Light Deprivation Condition:
Day 0: baseline fMRI
Day 1-7: exposition to 1 h complete darkness per day (12.00 – 1.00 p.m.)
Day 8: postintervention fMRI
Group 2: Light Desensitization Conditi
Sponsors
Universitätsklinik für NeurologieMedizinische Universität Wien
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients: o Migraine without aura according to the criteria of ICHD-III beta o Migraine present on 1 and 4 days per month in the 3 months preceding study inclusion o Intensity of interictal sensitivity to light 2 – 6 on a numeric rating scale with range 0-10 o Intensity of ictal sensitivity to light >4 on a numeric rating scale a numeric rating scale with range 0-10 Controls: o Matched for age, sex, education and socioecomic status to patients o No personal or family history of migraine o sensitivity to light <2 on a numeric rating scale
Exclusion criteria
Exclusion criteria: o Any other recurrent current or previous headache disorder apart from infrequent tension-type headache o Current or previous medication overuse o Pregnancy o Photosensitive epilepsy (excluded by a routine EEG) o Other current or previous brain disorders o Ophthalmological disorders relevant to the study o Psychiatric disorders relevant to the study o Other diseases relevant to the study including circadian rhythm disorders o Regular intake of centrally acting compounds including prophylactic medication for headache in the preceding three months o Shift and / or night work o Regular stay in unusually dark or bright environments o Light therapy within the preceding 3 months o Strategies to avoid exposure to light within the preceding 3 months o Claustrophobia o Metallic implants preventing fMRI o Current or history of substance abuse o Any other fMRI contraindications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a. Difference in mean total (i.e. ictal and interictal) sensitivity to light in the week after the intervention (days 8 – 14) between light exposure and light deprivation in patients with migraine b. Change in mean total sensitivity to light in the week after light exposure (days 8 – 14) compared to baseline (days -7 – -1) in patients with migraine c. Change in mean total sensitivity to light in the week after light deprivation (days 8 – 14) compared to baseline (days -7 – -1) in patients with migraine | — |
Secondary
| Measure | Time frame |
|---|---|
| a. Differences in mean interictal and mean ictal sensitivity to light in the week after the intervention (days 8 – 14) between light exposure and light deprivation in patients with migraine b. Changes in mean interictal and mean ictal sensitivity to light in the week after light exposure (days 8 – 14) compared to baseline (days -7 – -1) | — |
Countries
Austria
Contacts
Public ContactRoland Beisteiner
Universitätsklinik für NeurologieMedizinische Universität Wien
Outcome results
None listed