Aging
Conditions
Interventions
Group 1: (A) Randomly recruited age-stratified individuals from the general population covering the age range 35-74 years
(B) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspr
Sponsors
European Commission Directorate-General for Research and Innovation Health Research
Eligibility
Sex/Gender
All
Age
35 Years to 74 Years
Inclusion criteria
Inclusion criteria: Randomly recruited age-stratified individuals from the general population (both sexes) aged 35-74, who signed informed consent. Son or daughter of GEHA 90+ siblings, and their spouses; probands must be aged 55-74 who signed informed consent. Subjects affected by Down syndrome (DS), WS (Werner syndrome) and Cockayne syndrome (CS) that signed informed consent through their responsible family member or caregivers.
Exclusion criteria
Exclusion criteria: Subjects with any of the following characteristics were excluded from the study: [1] self reported seropositivity for HIV, HBV (except seropositivity by vaccination) and HCV; [2] seropositivity for HBV or HCV assessed after blood collection; [3] current cancer treatment or administration of glucocorticoids; [4] less than 50% of lifetime spent in country of residence; [5] inability to give informed consent. N.B. In the case of acute illness within the 7 days preceding the scheduled appointment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MARK-AGE aims the identification of powerful biomarkers of human ageing across a range of physiological systems | — |
Secondary
| Measure | Time frame |
|---|---|
| Recruitment of probands enables, in the first place, a cross-sectional approach to develop biomarkers of ageing. However, within the lifetime of the project (60 months), a limited random sample of probands will be re-tested in order to establish a longitudinal component within the study. | — |
Countries
Austria, Belgium, Finland, Germany, Greece, Italy, Netherlands, Poland
Contacts
Public ContactAlexander Buerkle
Universität Konstanz
Outcome results
None listed