Prevention of acute renal failure, molecular mechanism of dietary preconditioning in human.

Prevention of acute renal failure, molecular mechanism of dietary preconditioning in human. - CR_LSP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00007704

Enrollment

Registered

2015-10-14

Start date

2015-06-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N17

Interventions

Group 1: Donor receives calorie restricted formula diet, 50% of metabolic rate during 7 days prior to surgery, individually generated with Mifflin-St. Jeor formula. Group 2: Nutrition ad libitum, acco

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Competent persons > 18 years of age 2. Planned living kidney donation 3. Written informed consent under legal competence 4. BMI > 18.5 kg/m²

Exclusion criteria

Exclusion criteria: 1. Competent persons < 18 years of age 2. BMI < 18.5 kg/m²

Design outcomes

Primary

Measure	Time frame
Analysis of following outcomes from biopsy of donor's kidney: - Transkriptom - Lipidom - Metabolom - Epigenom - Proteom - Phosphoproteom	—

Secondary

Measure	Time frame
- Change in NGAL (µg/L) in urine (prior to surgery in donor and recipient; 6h, 12h and 24h after surgery only in recipient) - Cystatin C (prior to surgery in recipient; daily sampling until the 7th day after surgery only in recipient) - Occurrence of acute renal failure in accordance with KDIGI I, II, III - maximum serum creatinine during hospital stay after surgery	—

Countries

Germany

Contacts

Public ContactCornelia Böhme

Universitätsklinikum Köln (AöR) Klinik II für Nephrologie

studienzentrum-medII@uk-koeln.de+49 221 478 97222

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026