C71 D32 D33
Conditions
Interventions
Group 1: Primary brain tumors (radiotherapy with protons
2.0 Gy / Fx, total dose 54-60 Gy)
Group 2: Postoperative brain tumors (radiotherapy with protons
2.0 Gy / Fx, total dose 54-60 Gy)
Group 3: Recurrent brain tumors (radiotherapy with protons
2.0 to 5 Gy / Fx, total dose of 30-50 Gy)
Group 4: Glioblastomas in patients >70 years (radiotherapy with protons
moderate hypofractionated 2.67 to 40 Gy (RBE))
Sponsors
Universitätsklinikum DresdenKlinik für Strahlentherapie und Radioonkologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - brain tumor: gliomas (low or high grade), meningiomas, pituitary adenoma, craniopharyngiomas and other rare brain tumors and AV malformations - Age >= 18 years old - ECOG > 2 - Indication for high-dose radiotherapy or radiochemotherapy - Capacity to consent and written consent of the patient
Exclusion criteria
Exclusion criteria: - Lack of capacity to consent or lack of written consent of the patient - Inability to MRI planning (eg. contraindications to performing MRI) - Lack of compliance of the patient - Lack of or limited possibility of a reproducible storage (eg by severe restriction of mobility of the patient)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| >= grade late II toxicity after 2 years, evaluation by Kaplan-Meier plots | — |
Secondary
| Measure | Time frame |
|---|---|
| local tumor control and acute toxicity > stage II after 2 years, evaluation by Kaplan-Meier plots | — |
Countries
Germany
Contacts
Public ContactAnnett Petzold
Universitätsklinikum DresdenKlinik und Poliklinik für Strahlentherapie und RadioonkologieKlinisches Studienzentrum
Outcome results
None listed