D64.9
Conditions
Interventions
Group 1: In the study, synthetic polysulfone dialysers (Fresenius Medical Care Deutschland
GmbH, Bad Homburg) were used exclusively. For patients on low-flux dialysis, surface areas
between 1.3 and 2.
Sponsors
University of Würzburg Department of Internal medicine Division of Nephrology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with CKD who were treated by hemodialysis had to be at least 18 years of age and to have been receiving treatment for anemia with the ESA darbepoetin-alfa for at least 6 months.
Exclusion criteria
Exclusion criteria: Exclusion criteria were serious comorbid conditions with a life expectancy of < 2 years, single-needle hemodialysis, use of a permanent catheter, planned kidney transplantation, and pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study was the effect of high-flux versus low-flux hemodialysis on hemoglobin concentration. Therefore, the intraindividual change in hemoglobin concentration between beginning (month 0) and end (month 12) of the study period was calculated and compared between the two treatment groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints were the effects of high-flux versus low-flux hemodialysis on inflammatory status, oxidative stress, and nutritional status. As was done for calculations of the primary endpoint, the intraindividual changes in albumin, hsCRP, oxidative LDL, and myeloperoxidase concentrations between months 0 and 12 were determined and compared between the two treatment groups. | — |
Countries
Germany
Contacts
Public ContactAndreas Schneider
University of Würzburg Department of Internal medicine Division of Nephrology
Outcome results
None listed