I25.9
Conditions
Interventions
Group 1: 40 patients are operated on with a classical heart-lung-machine (HLM) and scheduled for at least three distal anastomoses to the coronary arteries. Furthermore, patients are randomized for an
Sponsors
Univeristät UlmKlinik für Herz-, Thorax- undGefäßchirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. isolated coronary artery disease, equally treatable with all three surgical techniques of the study 2. at least three graftable target coronary arteries
Exclusion criteria
Exclusion criteria: 1. Emergency operation (unstable condition, inotropic support, operation 85 years 6. Preoperatively known specific anatomical conditions preventing a randomisation of surgical technique (e.g. porcelain aorta)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total heparin and protamine dose during operation | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical relevant parameters (postoperative drainage blood loss, usage of blood/blood products), markers of coagulation system (PTT, INR, platelets, coagulation factors I, II, V, VIII, X, ATIII, TAT, TFPI, PTF1.2, d-dimer), of the renal system (crea, urea, eGFR, KIM I, NGAL, alphaGST, L-FABP), and of the inflammation system (CRP, leuco, TNFalpha, Pselectin, ICAM1) are measured and compared. | — |
Countries
Germany
Contacts
Public ContactHagen Gorki
Univeristät UlmKlinik für Herz-, Thorax- undGefäßchirurgie
Outcome results
None listed