C34
Conditions
Interventions
Group 1: Group A - Tumor Patients:
Intraoperatively, the patient is treated according to incision and prior removal of the primary or secondary tumors, approximately 20 ml of blood were taken off via
Sponsors
Universitätsklinikum Freiburg - Klinik für Thoraxchirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Group A: - submission of written consent from the patient after informing - Age = 18 years Diagnosis of primary lung carcinoma or pulmonary metastases - indication for surgical resection (atyp. Resection, lobectomy, Pneumonectomy, metastasisctomy) - In patients who are operated on a malignancy, the Histopathological findings including the adequate examinations be. No additional biopsy, examination or intervention must be within the framework Of the study. Group B: -template the written consent of the patient after informing - Age = 18 years - Patients who have neither a history nor a suspected malignancy (Other than basal cell carcinoma) and a lung operation due to a benign Cause a basic disease.
Exclusion criteria
Exclusion criteria: Group A: pregnancy - Diagnosis of a second (synchronous) malignoma, except basal cell carcinoma. - hemoglobin <8 g / dl on the morning of operation - Intraoperative transfusion of more than four erythrocyte concentrates Group B: pregnancy - Diagnosis of malignancy other than basal cell carcinoma. - hemoglobin <8 g / dl on the morning of operation - Intraoperative transfusion of more than four erythrocyte concentrates. No more Blood collection will be taken during or on the first postoperative day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creation of a molecular profile of the present tumor disease using the Analysis of CTCs and circulating nucleic acids in the local tumor compartment and systemically in primary and secondary lung tumors | — |
Secondary
| Measure | Time frame |
|---|---|
| - Tumor recidiv - Overall survival - Genetic consistency of the CTCs in the local tumor compartment and systemic - Comparison of different methods and removal points for the isolation of CTCs -comparison cDNA, miRNA and clncRNA in the surgical preparation with the circulating RNAs systemically as well as from the immediate tumor discharge - Expression of driver mutations of the CTCs | — |
Countries
Germany
Contacts
Public ContactSeverin Schmid
UNIVERSITÄTSKLINIKUM FREIBURGDepartment ChirurgieKlinik für Thoraxchirurgie
Outcome results
None listed