Nasal noninvasive high frequency oscillatory ventilation in premature infants below 32 weeks gestational age - a pilot study

Nasal noninvasive high frequency oscillatory ventilation in premature infants below 32 weeks gestational age - a pilot study - Nasal HFOV for premature infants

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00007171

Enrollment

Registered

2015-06-16

Start date

2014-07-20

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CO2 clearance using nasal high frequency oscillation

Interventions

Group 1: Premature infants < 32 weeks of gestational age will be treated 4 hours with nCPAP and 4 h with nHFOV using a crossover design within 24 hours after being extubated or receiving surfactant. A

Eligibility

Sex/Gender

All

Age

No minimum to 28 Days

Inclusion criteria

Inclusion criteria: 1. Premature infants 45 mmHg 4. Informed consent of caretakers

Exclusion criteria

Exclusion criteria: 1. Upper airway malformation leading to incompatibility with noninvasive ventilation 2. Known chomosomal abnormalities 3. Palliative/comfort care only.

Design outcomes

Primary

Measure	Time frame
Invasive measurement of partial pressure of carbon dioxide after 4 h nHFOV vs 4 h nCPAP	—

Secondary

Measure	Time frame
• Amplitude to achieve visible, adequate oscillation • mean airway pressure • need for intubation (failure of noninvasive ventilation per period) • Number of apnea/bradycardia per period • Respiratory rate* • Heart rate* • EDIN-Painscore* • SpO2* • FiO2* • pO2* • Transcutaneous pCO2 *after 4 hours of each type of ventilation	—

Countries

Germany

Contacts

Public ContactDaniel Klotz

Universitätskinderklinik Freiburg, Abteilung für Neonatologie

daniel.klotz@uniklinik-freiburg.de+49 761-270-43840

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 26, 2026